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Found 18 result(s)
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The Toxin and Toxin Target Database is a unique bioinformatics resource that combines detailed toxin data with comprehensive toxin target information. The focus of the T3DB is on providing mechanisms of toxicity and target proteins for each toxin. This dual nature of the T3DB, in which toxin and toxin target records are interactively linked in both directions, makes it unique from existing databases.
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The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information. The latest release of DrugBank (version 5.1.1, released 2018-07-03) contains 11,881 drug entries including 2,526 approved small molecule drugs, 1,184 approved biotech (protein/peptide) drugs, 129 nutraceuticals and over 5,751 experimental drugs. Additionally, 5,132 non-redundant protein (i.e. drug target/enzyme/transporter/carrier) sequences are linked to these drug entries. Each DrugCard entry contains more than 200 data fields with half of the information being devoted to drug/chemical data and the other half devoted to drug target or protein data.
The long-term goal of this project is to implement a new strategy for preserving and providing access to the Astrophysical data heritage. IA2 is an ambitious Italian Astrophysical research infrastructure project that aims at co-ordinating different national initiatives to improve the quality of astrophysical data services. It aims at co-ordinating these developments and facilitating access to this data for research purposes. The first working target, is the implementation of the TNG Long-Term Archive (LTA). Its feasibility was demonstrated by the LTA pilot project prototype, funded by CNAA in 2001 and completed successfully in July 2002. The implementation of the TNG archive implies: − interfacing with the Centro "Galileo Galilei" (CGG) for the acquisition of TNG data; − long-term storage of scientific, technical and auxiliary data from the TNG; − providing accessibility by the CGG staff and by the scientific community to original and derived data; − providing tools to support the life cycle of observing proposals. The second target of the proposal aims at ensuring harmonization with other projects related to archiving of data of astrophysical interest, with particular reference to projects involving the Italian astronomical community (LBT, VST, GSC-II, DPOSS, …), to the Italian Solar and Solar System Physics community (SOLAR, SOLRA, ARTHEMIS which form SOLARNET – a future node of EGSO) and to the national and international coordination efforts fostering the idea of a multiwavelength Virtual Astronomical Observatory, and the use of the archived data through the Italian Astronomical Grid.
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SIDER contains information on marketed medicines and their recorded adverse drug reactions. The information is extracted from public documents and package inserts. The available information include side effect frequency, drug and side effect classifications as well as links to further information, for example drug–target relations.
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<<<!!!<<< 2019-12-23: the repository is offline >>>!!!>>> Introduction of genome-scale metabolic network: The completion of genome sequencing and subsequent functional annotation for a great number of species enables the reconstruction of genome-scale metabolic networks. These networks, together with in silico network analysis methods such as the constraint based methods (CBM) and graph theory methods, can provide us systems level understanding of cellular metabolism. Further more, they can be applied to many predictions of real biological application such as: gene essentiality analysis, drug target discovery and metabolic engineering
PHI-base is a web-accessible database that catalogues experimentally verified pathogenicity, virulence and effector genes from fungal, Oomycete and bacterial pathogens, which infect animal, plant, fungal and insect hosts. PHI-base is therfore an invaluable resource in the discovery of genes in medically and agronomically important pathogens, which may be potential targets for chemical intervention. In collaboration with the FRAC team, PHI-base also includes antifungal compounds and their target genes.
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BACTIBASE contains calculated or predicted physicochemical properties of bacteriocins produced by both Gram-positive and Gram-negative bacteria. The information in this database is very easy to extract and allows rapid prediction of relationships structure/function and target organisms of these peptides and therefore better exploitation of their biological activity in both the medical and food sectors.
Contraceptive prevalence and the unmet need for family planning are key indicators for measuring improvements in access to reproductive health as asserted in the 2030 Agenda for Sustainable Development under target 3.7. "By 2030, ensure universal access to sexual and reproductive health-care services, including for family planning, information and education, and the integration of reproductive health into national strategies and programmes".
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Human biomaterial banks (short: biobanks) are collections of human body substances (i.e. blood, DNA, urine or tissue) connected with disease specific information. This allow for research of relations between deseases and underlying (molecular) modifications and paves the way for developing target-oriented therapies ("personalized medicine"). The biobank material arises from samples taken for therapeutical or diagnostic reasons or is extracted in the context of clinical trials. An approval for usage by the patient is always needed prior to any research activities.
The International Union of Basic and Clinical Pharmacology (IUPHAR) / British Pharmacological Society (BPS) Guide to PHARMACOLOGY is an expert-curated resource of ligand-activity-target relationships, the majority of which come from high-quality pharmacological and medicinal chemistry literature. It is intended as a “one-stop shop” portal to pharmacological information and its main aim is to provide a searchable database with quantitative information on drug targets and the prescription medicines and experimental drugs that act on them. In future versions we plan to add resources for education and training in pharmacological principles and techniques along with research guidelines and overviews of key topics. We hope that the IUPHAR/BPS Guide to PHARMACOLOGY (abbreviated as GtoPdb) will be useful for researchers and students in pharmacology and drug discovery and provide the general public with accurate information on the basic science underlying drug action.
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>>>!!!<<<GeoConnections – Discovery Portal is closed now>>>!!!<<< Information Archived on the Web Information identified as archived on the Web is for reference, research or recordkeeping purposes. It has not been altered or updated after the date of archiving. Web pages that are archived on the Web are not subject to the Government of Canada Web Standards. As per the Communications Policy of the Government of Canada, you can request alternate formats. Please "contact us" to request a format other than those available.
>>> !!! the repository is offline !!! <<< More information see: https://dknet.org/about/NURSA_Archive All NURSA-biocurated transcriptomic datasets have been preserved for data mining in SPP through an enhanced and expanded version of Transcriptomine named Ominer. To access these datasets, dkNET provides users with the information of 527 transcriptomic datasets that contain data related to nuclear receptors and nuclear receptor coregulators in the NURSA Datasets table view and redirects users to the current SPP dataset page. Once users find the specific dataset of research interest, users can download the dataset by clicking DOI and then clicking the Download Dataset button at the Signaling Pathways Project webpage. See https://www.re3data.org/repository/r3d100013650
GRID-Geneva is a unique platform providing analyses and solutions for a wide range of environmental issues. GRID-Geneva serves primarily the needs of its three institutional partners - UNEP, the Swiss Federal Office for the Environment (FOEN) and the University of Geneva (UniGe) - which are linked by an ongoing, multi-year “Partnership Agreement”, along with other local-to-global stakeholders. GRID-Geneva is also a bilingual English and French centre and the key francophone link within the global GRID network of centres. GRID-Geneva is a key centre of geo-spatial know-how, with strengths in GIS, IP/remote sensing and statistical analyses, integrated through modern spatial data infrastructures and web applications. Working at the interface between scientific information and policy/decision-making, GRID-Geneva also helps to develop capacities in these fields of expertise among target audiences, countries and other groups.
The EUDAT project aims to contribute to the production of a Collaborative Data Infrastructure (CDI). The project´s target is to provide a pan-European solution to the challenge of data proliferation in Europe's scientific and research communities. The EUDAT vision is to support a Collaborative Data Infrastructure which will allow researchers to share data within and between communities and enable them to carry out their research effectively. EUDAT aims to provide a solution that will be affordable, trustworthy, robust, persistent and easy to use. EUDAT comprises 26 European partners, including data centres, technology providers, research communities and funding agencies from 13 countries. B2FIND is the EUDAT metadata service allowing users to discover what kind of data is stored through the B2SAFE and B2SHARE services which collect a large number of datasets from various disciplines. EUDAT will also harvest metadata from communities that have stable metadata providers to create a comprehensive joint catalogue to help researchers find interesting data objects and collections.
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To target the multidisciplinary, broad scale nature of empirical educational research in the Federal Republic of Germany, a networked research data infrastructure is required which brings together disparate services from different research data providers, delivering services to researchers in a usable, needs-oriented way. The Verbund Forschungsdaten Bildung (Educational Research Data Alliance, VFDB) therefore aims to cooperate with relevant actors from science, politics and research funding institutes to set up a powerful infrastructure for empirical educational research. This service is meant to adequately capture specific needs of the scientific communities and support empirical educational research in carrying out excellent research.
Argo is an international programme using autonomous floats to collect temperature, salinity and current data in the ice-free oceans. It is teamed with the Jason ocean satellite series. Argo will soon reach its target of 3000 floats delivering data within 24 hours to researchers and operational centres worldwide. 23 countries contribute floats to Argo and many others help with float deployments. Argo has revolutionized the collection of information from inside the oceans. ARGO Project is organized in regional and national Centers with a Project Office, an Information Center (AIC) and 2 Global Data Centers (GDAC), at the United States and at France. Each DAC submits regularly all its new files to both USGODAE and Coriolis GDACs.The whole Argo data set is available in real time and delayed mode from the global data centres (GDACs). The internet addresses are: https://nrlgodae1.nrlmry.navy.mil/ and http://www.argodatamgt.org
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The Swedish Human Protein Atlas project has been set up to allow for a systematic exploration of the human proteome using Antibody-Based Proteomics. This is accomplished by combining high-throughput generation of affinity-purified antibodies with protein profiling in a multitude of tissues and cells assembled in tissue microarrays. Confocal microscopy analysis using human cell lines is performed for more detailed protein localization. The program hosts the Human Protein Atlas portal with expression profiles of human proteins in tissues and cells. The main objective of the resource centre is to produce specific antibodies to human target proteins using a high-throughput production method involving the cloning and protein expression of Protein Epitope Signature Tags (PrESTs). After purification, the antibodies are used to study expression profiles in cells and tissues and for functional analysis of the corresponding proteins in a wide range of platforms.