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OLOS is a Swiss-based data management portal tailored for researchers and institutions. Powerful yet easy to use, OLOS works with most tools and formats across all scientific disciplines to help researchers safely manage, publish and preserve their data. The solution was developed as part of a larger project focusing on Data Life Cycle Management (dlcm.ch) that aims to develop various services for research data management. Thanks to its highly modular architecture, OLOS can be adapted both to small institutions that need a "turnkey" solution and to larger ones that can rely on OLOS to complement what they have already implemented. OLOS is compatible with all formats in use in the different scientific disciplines and is based on modern technology that interconnects with researchers' environments (such as Electronic Laboratory Notebooks or Laboratory Information Management Systems).
Rhea is a freely available and comprehensive resource of expert-curated biochemical reactions. It has been designed to provide a non-redundant set of chemical transformations for applications such as the functional annotation of enzymes, pathway inference and metabolic network reconstruction. There are three types of reaction participants (reactants and products): Small molecules, Rhea polymers, Generic compounds. All three types of reaction participants are linked to the ChEBI database (Chemical Entities of Biological Interest) which provides detailed information about structure, formula and charge. Rhea provides built-in validations that ensure both mass and charge balance of the reactions. We have populated the database with the reactions found in the enzyme classification (i.e. in the IntEnz and ENZYME databases), extending it with additional known reactions of biological interest. While the main focus of Rhea is enzyme-catalysed reactions, other biochemical reactions (including those that are often termed "spontaneous") also are included.
The Swiss HIV Cohort Study (SHCS), established in 1988, is a systematic longitudinal study enrolling HIV-infected individuals in Switzerland. It is a collaboration of all Swiss University Hospital infectious disease outpatient clinics, two large cantonal hospitals, all with affiliated laboratories, and with affiliated smaller hospitals and private physicians carrying for HIV patients. The Swiss Mother and Child HIV Cohort Study (MoCHiV) is integrated into the SHCS. It aims at preventing mother to child transmission and enrolls HIV-infected pregnant women and their children. The SHCS involves practically all researchers being active in patient-oriented HIV research in Switzerland. The clinics can delegate recruitment of participants and follow-up visits to other outpatient clinics or to specialized private physicians, provided that the requirements of the protocol can be entirely fulfilled and controlled. The laboratories can contract other laboratories for some of the analyses.
Institutional repository of the University of Bern. BORIS Portal allows researchers at the University of Bern to archive and manage research data as well as project and funding information, to make it accessible and clearly identifiable.