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Found 58 result(s)

Huntingtin Interaction Network

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<<<!!!<<< This repository is no longer available. >>>!!!>>> The main objective of our work is to understand the pathomechanisms of late onset neurodegenerative disorders such as Huntington's, Parkinson's, Alzheimer's and Machado Joseph disease and to develop causal therapies for them. The disease causing proteins of these illnesses have been identified, but their functions in the unaffected organism are mostly unknown. Here, we have developed a strategy combining library and matrix yeast two-hybrid screens to generate a highly connected PPI network for Huntington's disease (HD).

NAGRP Blast Center

National Animal Genome Research Program Blast Center

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NAGRP Blast Center aggregates various sequence databases and makes them accessible via its website.

Birdbase

A database of avian genes & genomes

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<<<!!!<<< This repository is no longer available. >>>!!!>>> The sequencing of several bird genomes and the anticipated sequencing of many more provided the impetus to develop a model organism database devoted to the taxonomic class: Aves. Birds provide model organisms important to the study of neurobiology, immunology, genetics, development, oncology, virology, cardiovascular biology, evolution and a variety of other life sciences. Many bird species are also important to agriculture, providing an enormous worldwide food source worldwide. Genomic approaches are proving invaluable to studying traits that affect meat yield, disease resistance, behavior, and bone development along with many other factors affecting productivity. In this context, BirdBase will serve both biomedical and agricultural researchers.

PRO-ACT

Pooled Resource Open-Access ALS Clinical Trials Database

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The PRO-ACT platform houses the largest ALS clinical trials dataset ever created. It is a powerful tool for biomedical researchers, statisticians, clinicians, or anyone else interested in "Big Data." PRO-ACT merges data from existing public and private clinical trials, generating an invaluable resource for the design of future ALS clinical trials. The database will also contribute to the identification of unique observations, novel correlations, and patterns of ALS disease progression, as well as a variety of still unconsidered analyses. More than 600,000 people around them world are battling ALS. The disease strikes indiscriminately, and typically patients will die within 2-5 years following diagnosis. Currently, there are no effective treatments or a cure for ALS. Users of PRO-ACT are helping to accelerate the discovery, development, and delivery of ALS treatments, which will provide hope to patients and their families.

Wissenschaftliche Sammlungen

Wissenschaftliche Sammlungen in Deutschland und ihre Digitalisierung

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The portal "Wissenschaftliche Sammlungen" is a project of the Coordination Office for Academic University Collections in Germany in cooperation with the Academic University and University Collections. Together we create a platform that makes information on scientific collections, activities and actors as well as metadata and digitised objects visible, searchable and scientifically usable via a web portal. The data will be freely and openly accessible via technical interfaces in standard formats and fed into national reference systems such as the German Digital Library.

GiardiaDB

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Giardia lamblia is a significant, environmentally transmitted, human pathogen and an amitochondriate protist. It is a major contributor to the enormous worldwide burden of human diarrheal diseases, yet the basic biology of this parasite is not well understood. No virulence factor has been identified. The Giardia lamblia genome contains only 12 million base pairs distributed onto five chromosomes. Its analysis promises to provide insights about the origins of nuclear genome organization, the metabolic pathways used by parasitic protists, and the cellular biology of host interaction and avoidance of host immune systems. Since the divergence of Giardia lamblia lies close to the transition between eukaryotes and prokaryotes in universal ribosomal RNA phylogenies, it is a valuable, if not unique, model for gaining basic insights into genetic innovations that led to formation of eukaryotic cells. In evolutionary terms, the divergence of this organism is at least twice as ancient as the common ancestor for yeast and man. A detailed study of its genome will provide insights into an early evolutionary stage of eukaryotic chromosome organization as well as other aspects of the prokaryotic / eukaryotic divergence.

CSISA Data Repository

Cereal Systems Initiative for South Asia (CSISA) Research Data

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In keeping with the open data policies of the U.S. Agency for International Development (USAID) and Bill & Melinda Gates Foundation, the Cereal Systems Initiative for South Asia (CSISA) has launched the CSISA Data Repository to ensure public accessibility to key data sets, including crop cut data- directly observed, crop yield estimates, on-station and on-farm research trial data and socioeconomic surveys. CSISA is a science-driven and impact-oriented regional initiative for increasing the productivity of cereal-based cropping systems in Bangladesh, India and Nepal, thus improving food security and farmers’ livelihoods. CSISA generates data that is of value and interest to a diverse audience of researchers, policymakers and the public. CSISA’s data repository is hosted on Dataverse, an open source web application developed at Harvard University to share, preserve, cite, explore and analyze research data. CSISA’s repository contains rich datasets, including on-station trial data from 2009–17 about crop and resource management practices for sustainable future cereal-based cropping systems. Collection of this data occurred during the long-term, on-station research trials conducted at the Indian Council of Agricultural Research – Research Complex for the Eastern Region in Bihar, India. The data include information on agronomic management for the sustainable intensification of cropping systems, mechanization, diversification, futuristic approaches to sustainable intensification, long-term effects of conservation agriculture practices on soil health and the pest spectrum. Additional trial data in the repository includes nutrient omission plot technique trials from Bihar, eastern Uttar Pradesh and Odisha, India, covering 2012–15, which help determine the indigenous nutrient supplying ability of the soil. This data helps develop precision nutrient management approaches that would be most effective in different types of soils. CSISA’s most popular dataset thus far includes crop cut data on maize in Odisha, India and rice in Nepal. Crop cut datasets provide ground-truthed yield estimates, as well as valuable information on relevant agronomic and socioeconomic practices affecting production practices and yield. A variety of research data on wheat systems are also available from Bangladesh and India. Additional crop cut data will also be coming online soon. Cropping system-related data and socioeconomic data are in the repository, some of which are cross-listed with a Dataverse run by the International Food Policy Research Institute. The socioeconomic datasets contain baseline information that is crucial for technology targeting, as well as to assess the adoption and performance of CSISA-supported technologies under smallholder farmers’ constrained conditions, representing the ultimate litmus test of their potential for change at scale. Other highly interesting datasets include farm composition and productive trajectory information, based on a 20-year panel dataset, and numerous wheat crop cut and maize nutrient omission trial data from across Bangladesh.

Australian Drosophila Ecology and Evolution Resource

ADEER

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The Australian Drosophila Ecology and Evolution Resource (ADEER) from the Hoffmann lab and other contributors is a nationally significant life science collection. The Drosophila Clinal Data Collection contains data on populations along the eastern coast of Australia. It remains an excellent resource for understanding past and future evolutionary responses to climate change. The Drosophila Genomic Data Collection hosts Drosophila genomes sequenced as part of the Genomic Basis for Adaptation to Climate Change Project. 23 genomes have been sequenced as part of this project. Currently assemblies and annotations are available for Drosophila birchii, D. bunnanda, D. hydei, and D. repleta. The Drosophila Species Distribution Data Collection contains distribution data of nine drosophilid species that have been collected in Australia by the Hoffmann lab and other research groups between 1924 and 2005. More than 300 drosophilid species have been identified in the tropical and temperate forests located on the east coast of Australia. Many species are restricted to the tropics, a few are temperate specialists, and some have broad distributions across climatic regions. Their varied distribution along the tropical - temperate cline provide a powerful tool for studying climate adaptation and species distribution limits.